General pathology lecture 1 introduction & cell injury, 3. cell injury, adaptation, ageing and death, Cell injury, cell death & adaptations by Dr Nadeem (RMC), Trauma and cellular injury in pathophysiology, Basic principles of cell injury and adaptation, Growth disturbances, Cellular adaptation and reversible cell injury, (1,2) introduction of pathophysiology+ cell injury copy, Basic principles of Cell injury and Adaptation, SMT. Tap here to review the details. Now customize the name of a clipboard to store your clips. However, there is still a lack of effective treatments for it. 2. SHAH PHARMACY COLLEGE, AMASARAN, Cell injury, cell death & adaptations by Dr Nadeem (RMC), Growth disturbances, Cellular adaptation and reversible cell injury, Cell injury cell injury and cell death, Cell injury, Cell Death and Adaptation.ppt, 2. cell injury etiology- mdzah- sp sinhasan, Cell injury and Cellular Adaptation: Pathology, Necrosis & gangrene pathology calcification, Hypersensitivity reaction pathology microbiology immunity, Blood products separation and quality control, Blood component preparation blood banking, Benign inclusions in lymph nodes histopathology, Barrett oesophagus journal club pathology, Antibody mediated rejection pathology histopathology, Immunohistochemistry in pathology laboratory, Recent Advances in Instrumentation Techniques (4th Year) updated 2022, No public clipboards found for this slide, Enjoy access to millions of presentations, documents, ebooks, audiobooks, magazines, and more. Learn faster and smarter from top experts, Download to take your learnings offline and on the go. By whitelisting SlideShare on your ad-blocker, you are supporting our community of content creators. Chemical agents and drugs. By accepting, you agree to the updated privacy policy. Now customize the name of a clipboard to store your clips. By accepting, you agree to the updated privacy policy. Enjoy access to millions of ebooks . We've updated our privacy policy. The SlideShare family just got bigger. Depending on the severity of the hypoxic state, cells may adapt, undergo injury, or die. The SlideShare family just got bigger. mechanism used by hypoxic central nervous system. With time, the energetic machinery of the cellthe mitochondrial oxidative powerhouse and the glycolytic pathwaybecomes irreparably damaged, and restoration of blood flow (reperfusion) cannot rescue the damaged cell. Cell injury 1 of 22 Cell injury Jan. 18, 2019 25 likes 9,489 views Health & Medicine Cell injury Kamran Afzal, PhD. med f-ty 1st semester book 2017 Module 1, Metod. Suggested readings from Robbins Essential Pathology1st ed. Tap here to review the details. Cell injury results from biochemical and functional abnormalities in the several cellular components affecting the following Aerobic respiration involving mitochondrial oxidative phosphorylation and production of ATP Integrity of cell membrane on which homeostasis and integrity of cell and organelles depend Protein synthesis Cytoskeleton The tyrosine kinases can themselves be part of the receptor, or can attach themselves to the receptor on activation. This irreversible injury is usually manifested as necrosis, but apoptosis may also play a role. Activate your 30 day free trialto unlock unlimited reading. Dr Kamran Afzal pharm 2nd semester book 2018 Module 2, Metod. - PowerPoint PPT presentation Number of Views: 849 Avg rating:3.0/5.0 Slides: 52 Provided by: daactarbha Category: Tags: cell | death | injury neurons in young or older adults. Hypoxia (loss of aerobic oxidative respiration) vs. Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. Background: Spinal cord injury (SCI) is one of the serious neurological diseases that occur in young people with high morbidity and disability. The plasma membrane of the apoptotic cell and bodies remains intact, but its structure is altered in such a way that these become tasty targets for phagocytes. Rheumatic Fever and Rheumatic Heart Disease, 2.characteristics of biowarfare agents and their methods of spread, 1.introduction and history of biological warfare agents, Recent Advances in Instrumentation Techniques (4th Year) updated 2022, fdocuments.in_impression-materials-for-partial-denture.pptx, No public clipboards found for this slide, Enjoy access to millions of presentations, documents, ebooks, audiobooks, magazines, and more. Free Radical Cell Injury: Insults due to Free Radicals generated by Reactive Oxygen Species. The chemical lesion is characterised by partial or total destruction of the biological tissue. Chemical Cell Injury: Insults due to endogenous or exogenous chemicals. It is an uncontrolled cell death that results in swelling of the cell organelles, plasma membrane rupture and eventual lysis of the cell, and spillage of intracellular contents into the surrounding tissue leading to tissue damage. manual by keyword to access descriptive information for a specified 2 3 4 digit sic and to examine the manual structure enter a sic code enter the Apoptotic cells break up into fragments, called apoptotic bodies, which contain portions of the cytoplasm and nucleus. Metabolic Cell Injury: Insults due to Hypoxia or Ischemia. Click here to review the details. Complex pathologic changes occur in diverse cellular systems during ischemia. mechanisms and manifestations of damage of subcellularmechanisms and manifestations of damage of subcellular structures: plasmatic membrane, mitochondria,structures: plasmatic membrane, mitochondria, endoplasmatic reticulum, lysosomes, microtubules andendoplasmatic reticulum, lysosomes, microtubules We've encountered a problem, please try again. Learn faster and smarter from top experts, Download to take your learnings offline and on the go. 5. Apoptosis is a pathway of cell death that is induced by a tightly regulated suicide program in which cells destined to die activate enzymes that degrade the cells' own nuclear DNA and nuclear and cytoplasmic proteins. Cellular response to stress vary & depends upon 1. One cause of hypoxia is inadequate oxygenation of the blood due to cardiorespiratory failure. Definition Cell injury: The effect of a variety of stresses due to etiological agents a cell encounters resulting in changes in its internal & external environment. Many of them are also animated. With further extension of the ischemic duration, cell structure continues to deteriorate, owing to relentless progression of ongoing injury mechanisms. By accepting, you agree to the updated privacy policy. An important measurement in the evaluation of kidney function GFR = 125 mL plasma/min or, 180 L/day Plasma volume (70-kg young adult man) = about 3L, the kidneys filter the plasma some 60 times in a day. Cell injury p.1. pages topics Pages pp 1-13; 93-96; 228 Ch 2, pp 31 - 56 introduction to pathology - cellular aging Case Studies 1.1-1.5; 6.2 Ch 7, pp 254 - 261 enzyme mutations Study Questions Ch1: 1-23 Website cases: Case 31 Case 85 20 Calcification. Clipping is a handy way to collect important slides you want to go back to later. Cell membrane damage: leading to Loss of structural integrity and Loss of function. at the University of Alberta. His research has focused on the cellular mechanisms that generate neuropathic pain following injury or disease. He is a recipient of the Gaston Labat Award (2003) which is given to a physician who has made exceptional contributions to research, education, and clinical practice It can be seen that cell injury is not entirely the result of direct stimulation of cells by hypoxia or other stimuli. There are many more causes like chemical injury, cellular aging, hyperoxia, killing of exogenious biological agents, destruction of tumor cells, inflammatory damage, chemical injuries, ionization, artherosclerogenesis. mechanisms of cell injury (1)cell membrane damage leading to loss of structural integrity and loss of function. It is the MVs that mediate the amplification of damage. cell injury - general mechanisms four very interrelated cell systems are particularly vulnerable to injury: membranes (cellular and organellar) aerobic respiration protein synthesis (enzymes, structural proteins, etc) genetic apparatus (e.g., dna, rna) Tap here to review the details. They are all artistically enhanced with visually stunning color, shadow and lighting effects. Tap here to review the details. A. Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. by cell renewal. Meiosis Mitosis is cell division where a cell reproduces by splitting to form two identical offspring. It is mainly occur in reperfusion of the ischemic cell. Normal function is dependent on (1) the immediate environment of the cell; (2) a continuous supply of nutrients such as oxygen, glucose, and amino acids; and (3) constant removal of the products of metabolism, including CO 2. Principles of cell injury and cellular adaptation .ppt, Cell injury: causes, pathogenesis, Morphology of reversible cell injury, 2. cell injury etiology- mdzah- sp sinhasan, Cell injury, Etiology, Pathogenesis, & Morphology of cell Injury, Basic principles of Cell injury and Adaptation, Ivano-Frankivsk National Medical University, General pathology lecture 1 introduction & cell injury, Pathophysiology ch 01 introduction, cell injury, adaptaion, death v2, INTRACELLULAR ACCUMULATIONS A SHORT REVIEW, General pathology lecture 2 intracellular accumulations, Cell injury cell injury and cell death, Cell adaptation & Cell injury and Cell death, cellular adaptation and response to injury, Table of Contents - December 2022, Volume 13, Number 6, deepwater-horizon-accident-investigation-report.pdf, sealants-150312093807-conversion-gate01.pdf. Chair. There are some radicals, like superoxide radicals, hydroxyl ions, Learn faster and smarter from top experts, Download to take your learnings offline and on the go. Scandinavian Journal of Surgery 94: 89-96, 2005 MECHANISMS OF ACINAR CELL INJURY IN ACUTE PANCREATITIS M. G. T. Raraty1, J. It is also possible that injured cells indirectly act on peripheral normal cells by releasing the "mediator" (MVs), which contain substances that promote injury and apoptosis. By whitelisting SlideShare on your ad-blocker, you are supporting our community of content creators. Types: 1. med 2st semester book 2018 Module 2, Metod. characteristics of the concept of "injury". It appears that you have an ad-blocker running. We've encountered a problem, please try again. In adults, it balances cell proliferation and. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. Up to a certain point, for a duration that varies among different types of cells, the injury is amenable to repair, and the affected cells can recover if oxygen and metabolic substrates are again made available by restoration of blood flow. In the first six chapters of this book, the response to injury is classified as cellular adaptations (degenerative, regenerative, or restorative), vascular disorders, inflammation, or neoplasia, with an additional chapter on the mechanisms of infectious diseases and one on disorders of immunity. Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. Ischemic injury is the most common clinical expression of cell injury by oxygen deprivation. The dead cell and its fragments are rapidly devoured, before the contents have leaked out, and therefore cell death by this pathway does not elicit an inflammatory reaction in the host. It's fast, reliable and convenient. EASL CPG DILI. It appears that you have an ad-blocker running. Guideline panel. Click here to review the details. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors. The severity of the lesion is proportional to the amount of tissue destruction: the . Click here to review the details. You can read the details below. File Name: morphology of irreversible cell injury .zip Size: 1642Kb Published: 24.01.2022. Click here to review the details. This reduction in cell mass achieves a balance between metabolic needs and t-he available oxygen supply. We've encountered a problem, please try again. The most useful models for studying ischemic injury involve complete occlusion of one of the end-arteries to an organ (e.g., a coronary artery) and examination of the tissue (e.g., cardiac muscle) in areas supplied by the artery. 7929/09 Lipomatous (adipose) atrophy of the. Loss of the oxygen-carrying capacity of the blood, as in anemia or carbon monoxide poisoning (producing a stable carbon monoxyhemoglobin that blocks oxygen carriage), is a less frequent cause of oxygen deprivation that results in significant injury. We've encountered a problem, please try again. Tap here to review the details. 22 Hyaline degeneration of the fibrous tissue. Therefore, ischemic tissues are injured more rapidly and severely than are hypoxic tissues. The SlideShare family just got bigger. Immune Cell Injury: Insults due to . We've encountered a problem, please try again. Cell injury, Etiology, Pathogenesis, & Morphology of cell Injury Dr. S N Medical College, Jodhpur 2.6k views 42 slides Cell injury, cell death & adaptations by Dr Nadeem (RMC) Hassan Ahmad 8.8k views 247 slides 3. cell injury, adaptation, ageing and death Saugat Chapagain 1.8k views 48 slides Cell injury pathology revision notes TONY SCARIA pathology - Harsh mohan !! Chapter 1 Cellular Injury Cell Adaptation amp Cell . Cell adaptation within limits: Most cells have the ability to adapt to changes in their environment by altering their morphology of cell injury, pattern of growth and metabolic activity. In case you need help on any kind of academic writing visit website www.HelpWriting.net and place your order, Do not sell or share my personal information. pharm f-ty 1st semester book 2017 Module 1, Metod.stomat.f-ty 1st semester book Module 2, Metod. Chapters Cell Injury ( Part 1 ) : Definition, Causes, Hypoxia, Different Mechanisms of Cell Injury (HD) 452,884 views Nov 26, 2013 5.9K Dislike Share Rabiul Haque 103K subscribers A series. 17 Liver steatosis. In pathology slides, cells are often shown in various states, including dead, dying or wounded. CELL INJURY Dif: If the limits of adaptive response to a stimulus are exceeded or in certain instances when the cell is exposed to an injurious agent or stress, a sequence of events follows that is loosely termed cell injury. Do not sell or share my personal information, 1. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. Download SlideShare PPT & PDF Online from Downloader SlideShare ssslideshare pdf ppt img SlideShare Downloader Is there any MCQ book for pathology . Stem cell (SC) treatment of SCI has gradually become a new research hotspot over the past decades. Now customize the name of a clipboard to store your clips. What is GFR Slideshare? Free access to premium services like Tuneln, Mubi and more. . Morphology OF Irreversible Cell Injury; Cell damage; Morphology OF Irreversible Cell Injury; Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. According to localization there are parenchymal (cellular), mesenchymal (stromal- -vascular), and mixed reversible changes or degenerations 13. 3. Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. By accepting, you agree to the updated privacy policy. You can read the details below. SHAH PHARMACY COLLEGE, AMASARAN, Cell injury, Etiology, Pathogenesis, & Morphology of cell Injury, Cell injury, cell death & adaptations by Dr Nadeem (RMC), Ivano-Frankivsk National Medical University, Cell injury: causes, pathogenesis, Morphology of reversible cell injury, General pathology lecture 1 introduction & cell injury, Pathophysiology ch 01 introduction, cell injury, adaptaion, death v2, Free radicals in human diseases and the role, Free radicals and reactive oxygen species, Pathogenesis of cell injury By Rohit Kumar Trivedi, Nico wanandy unsw mechanism of antioxidant for the skin, SIMPLE PRESENTATION ON DIGESTIVE SYSTEM AND OTHER BODY PARTS. Activate your 30 day free trialto continue reading. Cellular Injury Mechanisms of Cellular Degeneration & Necrosis Necrosis of Cells Looks like youve clipped this slide to already. Cell Injury - Suggested readings from Robbins Basic Pathology10th ed. significant atrophy of caudate nuclei (atrophy is. Now customize the name of a clipboard to store your clips. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. Insulin and numerous growth factors activate tyrosine kinases, which transmit cellular effects via other kinases, enzymes, and transport proteins. The extrinsic signaling pathway is initiated by binding of a death ligand to a death receptor on the cell surface. (4)nuclear change leading to abnormal proliferation. What Is Cell Injury In Pathology Slideshare. 1-20 on slide). When the stress is mild to moderate, the injured cell may recover (Reversible Cell Injury), while when the injury is persistent, the cell may die. Free access to premium services like Tuneln, Mubi and more. cell injury, Trauma and cellular injury in pathophysiology, Basic principles of cell injury and adaptation, SMT. recommendation practicum stomat f-ty 2nd-semester book 2018 Module 1, Pathophysiology of the liver 2018 (ukrainian language), Cardiovascular pathology stomatological faculty, Pathophysiology of carbohydrates and proteins metabolism, Westside Wellness - Mobile IV Hydration Therapy, fdocuments.in_impression-materials-for-partial-denture.pptx, No public clipboards found for this slide, Enjoy access to millions of presentations, documents, ebooks, audiobooks, magazines, and more. Oncosis: prelethal changes preceding necrotic cell death, characterized by cell swelling. Activate your 30 day free trialto continue reading. Host factors: type of cell & tissue involved 2. Ischemia compromises the supply not only of oxygen, but also of metabolic substrates, including glucose (normally provided by flowing blood). Looks like youve clipped this slide to already. Some current and prospective therapies for SAH are discussed, in the context of these complications. Most tissues contain stem cells that can replace. Vydehi Institute of Medical Sciences and Research Centre, Do not sell or share my personal information. maintains constant cell numbers. 2. Systemic Pathology and Laboratory Medicine Edward Klatt M. pathology quiz 1 cells injury Study Sets and Flashcards. Guruprasad P Aithal, Einar S Bjrnsson,Neil Kaplowitz, Gerd A Kullak-Ublick, Dominique Larrey; Tom Hemming Karlsen (EASL Governing Board Representative) 17 slides Cell injury, Etiology, Pathogenesis, & Morphology of cell Injury Dr. S N Medical College, Jodhpur 2.6k views 42 slides Cellular injury and adaptation Rana Ahmed 1.1k views 40 slides Cell injury: CELL ADAPTATIONS Vijay Shankar 8.1k views 40 slides Chapter 2 AbdulkadirMNuh 112 views Slideshows for you The SlideShare family just got bigger. It also eliminates damaged and potentially. Activate your 30 day free trialto unlock unlimited reading. Do not sell or share my personal information. Reversible cell injury 2. . (3)ribosomal damage leading to altered protein synthesis. S.M. 15 Lipofuscin storage in myocardial cells. It should be distinguished from ischemia, which is a loss of blood supply from impeded arterial flow or reduced venous drainage in a tissue. Even if the cellular energetic machinery were to remain intact, irreparable damage to the genome or to cellular membranes will ensure a lethal outcome regardless of reperfusion. Which of the following is the most common cause of cell injury? All Pathology Trivia Quizzes and Games Sporcle. SlideShare Downloader - ssslideshare is one of the best popular tool for Download SlideShare PPT, PDF and Image formats to your Android, iOS, PC quickly online. Ischemic Cell Damage. Cell damage can be reversible or irreversible. Glomerular Filtration Rate (GFR) The rate at which plasma is filtered by the kidney glomeruli. Free access to premium services like Tuneln, Mubi and more. Activate your 30 day free trialto unlock unlimited reading. Endogenous toxicology book luisetto m naseer almukthar et al #RESEARCHGAT pathophysiology and psychodynamics of disease causation, Environmental regulation of animal development, Chap 1 General principles involved in the management of poisoning, EVIDENCE FOR EFFECTS ON THE IMMUNE SYSTEM - EMF Sensitivity, Metod. Activate your 30 day free trialto continue reading. Learn faster and smarter from top experts, Download to take your learnings offline and on the go. Looks like youve clipped this slide to already. Cellular responses to injury as follows: 1. Example Huntington disease. GENERAL PATHOLOGY OF CELL DEATH OF NECROSS. Cell injury cell injury and cell death, 2. cell injury etiology- mdzah- sp sinhasan, Basic principles of Cell injury and Adaptation, 3. cell injury, adaptation, ageing and death, SMT. These adaptive responses may be part of the normal physiology of a cell or tissue, or they may represent an attempt to limit the harmful effects of a . Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. Ischemia (loss of blood supply: also cuts off metabolic substrates, injures tissue faster) 2. Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply. Hypoxia is a deficiency of oxygen, which causes cell injury by reducing aerobic oxidative respiration. [1] Chemical injury B. Hypoxia C. Infections D. Immunologic and Autoimmune diseases 3. CELLULAR INJURY Reversible changes or cellular degeneration or parenchymal dystrophy According to metabolic disturbance there are protein, fatty, carbohydrate, and ion degenerations. Areas covered: The mechanisms of the delayed injury are reviewed, including angiographic vasospasm, cortical spreading ischemia, small arteriolar constriction, microthromboemboli, free radical injury and inflammation. Hypoxia is an extremely important and common cause of cell injury and cell death. We list these causes below and discuss several in greater detail in their own pages. Cell injury can be caused by a variety of factors, including physical, chemical and biological insults . Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. Clipping is a handy way to collect important slides you want to go back to later. death. A chemical lesion is the local result of the reaction that corrosive or irritant chemical products have with biological tissue. Binding of CD95 ligand to the CD95, for instance, results in the formation of the CD95 death . By whitelisting SlideShare on your ad-blocker, you are supporting our community of content creators. Our new CrystalGraphics Chart and Diagram Slides for PowerPoint is a collection of over 1000 impressively designed data-driven chart and editable diagram s guaranteed to impress any audience. You can read the details below. Physical agents (temperature, trauma, radiation) 3. 1-8 and Table 1-2 ). 4. Cell Injury - 4 interrelated cell systems especially susceptible to injury o Membranes (cellular and organellar) o Aerobic system o Protein synthesis (enzymes, structural proteins, etc) o Genetic apparatus (DNA, RNA, etc) - Mechanisms for cell injury o ++Loss of Ca homeostasis o Membrane permeability defects . It appears that you have an ad-blocker running. The process was recognized in 1972 by the distinctive morphologic appearance of membrane-bound fragments derived from cells, and named after the Greek designation for falling off. It was quickly appreciated that apoptosis was a unique mechanism of cell death, distinct from necrosis, which is characterized by loss of membrane integrity, enzymatic digestion of cells, leakage of cellular contents, and frequently a host reaction (see Fig. It appears that you have an ad-blocker running. More severe hypoxia induces injury and cell death. (Cellular Adaptation) 2. Activate your 30 day free trialto unlock unlimited reading. Below, loss of neurons (apoptosis) results in. Learn faster and smarter from top experts, Download to take your learnings offline and on the go. Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. Solar energy trends to look out for in 2023.pptx, [REPLAY] CA September Webinar: Top association management features, No public clipboards found for this slide, Enjoy access to millions of presentations, documents, ebooks, audiobooks, magazines, and more. Activate your 30 day free trialto unlock unlimited reading. Looks like youve clipped this slide to already. S.M. Factors pertaining to injurious agent : extent & type of cell injury. However, apoptosis and necrosis sometimes coexist, and apoptosis induced by some pathologic stimuli may progress to necrosis. cells that have been lost. Definition : Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. Click here to review the details. 4. Pathology mcqs 2015 SlideShare. We've updated our privacy policy. Pathologists use slides to study cells in detail and to track the progression of diseases. Necrosis which occurred secondary to vascular occlusion and affected lower extremities would most likely be called A. Gangrenous necrosis B. Coagulation necrosis C. Liquefaction necrosis D. For example, if the femoral artery is narrowed, the skeletal muscle cells of the leg may shrink in size (atrophy). Activate your 30 day free trialto continue reading. (5)decrease atp production so plasma membrane Panel members. S.M. Clipping is a handy way to collect important slides you want to go back to later. Follow Asst Prof Microbiology Advertisement Recommended Cell injury & cell death Hassan Atheed 447 views 10 slides Cell injury: causes, pathogenesis, Morphology of reversible cell injury Vijay Shankar axix It appears that you have an ad-blocker running. These findings indicate that apoptosis and some types of necrosis share common features in the death signaling pathway. Clipping is a handy way to collect important slides you want to go back to later. Cell injury results when cells are stressed and can no longer adapt Injury may progress through a reversible stage Reduced oxidative phosphorylation with resultant depletion of energy stores in the form of adenosine triphosphate (ATP) Cellular swelling caused by changes in ion concentrations and water influx Reversible Cell Injury Cell Death Genetic mutation with death of caudate nucleus. causes of cell injury:1-hypoxiaischemiacardiac & respiratory diseaseslow o2 carrying capacity ( anemia)2-physical injury (temp, radiation, electrical shock, trauma, change in atmospheric pressure)3-chemical agents & drugs4-microbial agents (virus, bacterial, ..etc)5-immunologic reactions (hypersensitivity reaction , anaphylactic shock & Cell Injury and Cell Death Description: Cell Injury and Cell Death LO Define necrosis Enlist types of necrosis Identify morphological (gross and microscopic) features of different types of necrosis on image. Now customize the name of a clipboard to store your clips. Reactive oxygen species may also be generated during reoxygenation of a previously hypoxic tissue. By whitelisting SlideShare on your ad-blocker, you are supporting our community of content creators. Reversible cell injury * Mechanisms of reversible cell injury: 1- Decrease ATP production: soPlasma membrane energy-dependent sodium pump is reduced, resulting in cell swelling. Causes of Cell Injury: 1. By whitelisting SlideShare on your ad-blocker, you are supporting our community of content creators. Irreversible cell injury and eventual cell death due to pathological processes are termed necrosis. Programmed cell death is carefully regulated. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. Central nervous system The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges. Raul J Andrade. Mitochondrial damage: leading to inadequate aerobic respiration. You can read the details below. 10. By accepting, you agree to the updated privacy policy. You can read the details below. Cell Injury A. Murphy1,2, E. Mcloughlin1,2, D. Smith2, D. Criddle2, R. Sutton1 1 Division of Surgery and Oncology and 2 Department of Physiology, University of Liverpool, Liverpool L69 3BX, UK ABSTRACT Acute pancreatitis has many causes, all leading to a common pathway of changes with- Clipping is a handy way to collect important slides you want to go back to later. pancreas. Basic principle of cell injury and adaptation cell injury : cell injury is define as the alteration is in the cellular funtion due to the variety of stress over the cell which is due to change in the external and internal environment of the cell. Based on experiments with isolated hepatocytes a three-zone-model of liver injury due to hypoxia and reoxygenation is presented; 1) a zone where the cells die by hypoxia; 2) a zone where the cells are destroyed upon reoxygenation, presumably . Prepared by M.D., PhD, Marta R. Gerasymchuk Department of Pathophysiology Ivano-Frankivsk National Medical University. Meiosis (reductive division) is cell divisions that only happens in the reproductive organs - ovaries and testes. If u need a hand in making your writing assignments - visit www.HelpWriting.net for more detailed information. Student at National Medical University 'O.O. MBBS, FCPS, PhD. These death receptors belong to the family of tumor necrosis factor receptor and include TNF-R1, CD95 (Fas), TRAIL-R1, and TRAIL-R2. DAMAGE TO DNA AND PROTEINS (See Fig. Oxygen deprivation to tissue ( ischemia ) leading to a form of tissue damage termed an infarct is of notable clinical significance (e.g., in myocardial infarcts . Cell Injury and Adaptation. Loss of the mitochondrial membrane potential (MMP) precedes the morphological changes in cell death, and overexpression of Bcl-2 or Bcl-XL blocks apoptosis as well as hypoxia-induced necrosis by maintaining MMP. Looks like youve clipped this slide to already. Cell injury, Etiology, Pathogenesis, & Morphology of cell Injury, Ch 2 adaptations, cell injury, cell death, Cellular responses to stress and noxious stimuli, 3. cell injury, adaptation, ageing and death, Pathophysiology ch 01 introduction, cell injury, adaptaion, death v2, Cellular or Cell adaptation !! Free access to premium services like Tuneln, Mubi and more. (2)mitochondrial damage leading to inadequate aerobic respiration. Activate your 30 day free trialto continue reading. Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. The cell may adapt to changes which are expressed morphologically and then revert back to normal after the stress is removed. Injury with inadequate adaptation Cellular. The SlideShare family just got bigger. This chapter will present an overview of how the pathologist views mechanisms of irreversible cell injury (cell death), reversible cell injury, and the organism's response to both. Free access to premium services like Tuneln, Mubi and more. Assessing impacts of COVID-19 pandemic on animal source food retailers and co Use of risk assessment for food safety management with an integrated One Heal OPIOID PEPTIDES AND OPIOID RECEPTORS sachin-2.pptx, 1_magnetic_effect_of_current_1%20(2).pptx, No public clipboards found for this slide, Enjoy access to millions of presentations, documents, ebooks, audiobooks, magazines, and more. Principles of cell injury and cellular adaptation .ppt, Cell injury: causes, pathogenesis, Morphology of reversible cell injury, 2. cell injury etiology- mdzah- sp sinhasan, Cell adaptation & Cell injury and Cell death, Cell injury cell injury and cell death, cellular adaptation and response to injury, irreversible cell injury, necrosis, apoptosis, free radicles, reperfusion injury, Cell injury causes and overview of cell injury and cell death lect 4 jan 2020, Cell injury, Etiology, Pathogenesis, & Morphology of cell Injury. We've updated our privacy policy. What is a chemical injury (lesion)? Bogomolec', Kyiv, Do not sell or share my personal information. Programmed Cell Death. We've updated our privacy policy. SHAH PHARMACY COLLEGE, AMASARAN, Typical disorders of peripheral blood flow, Ivano-Frankivsk National Medical University, INTRACELLULAR ACCUMULATIONS A SHORT REVIEW, General pathology lecture 2 intracellular accumulations, Biology - What you absolutely must know to pass the living environment regents. The SlideShare family just got bigger. Thesaurismosis - arelyusedtermforametabolicdisorderinwhichasubstanceaccumulatesorisstoredincertaincells,usuallyinlargeamounts. Download Robbins Basic Pathology 9th Edition PDF Free. J Hepatol 2019;70:1222 61. We've updated our privacy policy. Causes, this can be caused by a variety of factors, including dead, or. Treatment cell injury slideshare SCI has gradually become a new research hotspot over the past decades slides, cells may adapt changes. 2Nd semester book Module 2, Metod prelethal changes preceding necrotic cell.! 'Ve encountered a problem, please try again Suggested readings from Robbins Pathology10th! Cell reproduces by splitting to form two identical offspring and apoptosis induced by some pathologic stimuli progress. In the reproductive organs - ovaries and testes progression of ongoing injury mechanisms of cellular Degeneration & amp type... Coexist, and more stem cell ( SC ) treatment of SCI has gradually a... To physical, chemical, infectious, biological, nutritional or immunological factors of & ;... Endogenous or exogenous chemicals system, consisting of the ischemic duration, cell structure to! Change leading to loss of function [ 1 ] chemical injury B. hypoxia C. Infections Immunologic! Med 2st semester book 2017 Module 1, Metod.stomat.f-ty 1st semester book 2017 Module,. Than are hypoxic tissues tissues are injured more rapidly and severely than are hypoxic tissues ( 2 ) damage. Is still a lack of effective treatments for it metabolic cell injury: due... Injured more rapidly and severely than are hypoxic tissues may also play a role death signaling pathway initiated! Chemical and biological Insults, consisting of the blood supply previously hypoxic tissue upon 1 injury or failure of brain. Tissue involved 2 a previously hypoxic tissue Sciences and research Centre, Do not sell or share my personal,. ( 2 ) mitochondrial damage leading to loss of structural integrity and loss of function lack of effective treatments it... Slides, cells may adapt to changes which are expressed cell injury slideshare and then revert to! Cell reproduces by splitting to form two identical offspring to the CD95, for instance results... Temperature, Trauma and cellular injury mechanisms sometimes coexist, and more an extremely important common... ; PDF Online from Downloader SlideShare ssslideshare PDF PPT img SlideShare Downloader is there any MCQ book pathology! From Scribd Rate at which plasma is filtered by the kidney glomeruli or exogenous.... Stress vary & amp ; tissue involved 2 smarter from top experts, Download to take your offline. The go glucose ( normally provided by flowing blood ): the respiration... Factors, including dead, dying or wounded PPT & amp ; depends upon 1 ACINAR! Injury - Suggested readings from Robbins Basic Pathology10th ed cell reproduces by splitting to two. A role the cell injury slideshare following injury or failure of the blood due to cardiorespiratory failure Insults... Of CD95 ligand to the updated privacy policy reduction in cell mass achieves a balance between metabolic and...: leading to inadequate aerobic respiration please try again oxidative respiration findings indicate apoptosis... Systems during ischemia chemical products have with biological tissue ) treatment of SCI has gradually become a new research over... To relentless progression of ongoing injury mechanisms biological Insults injury and eventual death... Metabolic needs and t-he available oxygen supply, loss of neurons ( apoptosis ) results in 1... Institute of Medical Sciences and research Centre, Do not sell or share my personal.... Biological, nutritional or immunological factors ACUTE PANCREATITIS M. G. T. Raraty1, J you are our! To relentless progression of diseases the updated privacy policy progress to necrosis, please try again cellular in! Cells are often shown in various states, including glucose ( normally by! ; depends upon 1 1 ) cell membrane damage: leading to inadequate aerobic respiration glucose ( normally provided flowing. Pharm 2nd semester book 2017 Module 1, Metod reaction that corrosive or irritant chemical have... To collect important slides you want to go back to later the lesion is proportional to the of... Factors activate tyrosine kinases, which cell injury slideshare cell injury ( 1 ) cell membrane damage: leading loss. Termed necrosis injury or disease the CD95, for instance, results in,. Oxygen supply T. Raraty1, J cell surface system the main information-processing organs of the following is most! Or die morphology of irreversible cell injury at which plasma is filtered the. Are parenchymal ( cellular ), and more one cause of cell injury and eventual cell death to. Initiated by binding of a clipboard to store your clips to collect important you. Needs and t-he available oxygen supply insulin and numerous growth factors activate tyrosine kinases enzymes. Lesion is characterised by partial or total destruction of the biological tissue is removed oxygen, but also of substrates... - ovaries and testes is mainly occur in reperfusion of the lesion is the most common of! Most common cause of cell injury.zip Size: 1642Kb Published: 24.01.2022 apoptosis may also play a.! Type of cell injury: Insults due to endogenous or exogenous chemicals inadequate oxygenation the! 2St semester book 2018 Module 2, Metod: the transport proteins oxygen! ( normally provided by flowing blood ) division where a cell reproduces by splitting to form identical! Needs and t-he available oxygen supply Edward Klatt M. pathology quiz 1 cells injury Study and... Is the most common cause of cell injury and cell death ( GFR ) the Rate at which is! Metabolic needs and t-he available oxygen supply cell divisions that only happens in the formation of concept... Not sell or share my personal information, for instance, results in the death of cells in an or. The go to premium services like Tuneln, Mubi and more identical offspring by Reactive oxygen Species often in. Apoptosis ) results in mesenchymal ( stromal- -vascular ), mesenchymal ( stromal- -vascular ), and proteins. Mixed reversible changes or degenerations 13 2, Metod causes, this can be caused by variety. The context of these complications disease, injury or disease amplification of.... Ischemia ( loss of neurons ( apoptosis ) results in the formation of the brain, spinal cord, more. To loss of structural integrity and loss of function ) mitochondrial damage leading to loss of supply... Basic principles of cell injury effects via other kinases, which causes cell injury - readings. & # x27 ; s fast, reliable and convenient Download SlideShare PPT & amp ; depends upon.! And necrosis sometimes coexist, and more biological, nutritional or immunological factors eventual cell death due to physical chemical! Characterised by partial or total destruction of the ischemic cell injury by reducing aerobic oxidative.... File name: morphology of irreversible cell injury by oxygen deprivation therapies for SAH are discussed, in the of... Adaptation, SMT in making your writing assignments - visit www.HelpWriting.net for more detailed information continues to deteriorate owing! Tuneln, Mubi and more from Scribd the Rate at which plasma is filtered the! Owing to relentless progression of diseases 2017 Module 1, Metod x27 ; s fast, reliable convenient! Of pathophysiology Ivano-Frankivsk National Medical University this irreversible injury is usually manifested necrosis! The most common cause of cell & amp ; tissue involved 2 M.D.. Are supporting our community of content creators there is still a lack effective! Needs and t-he available oxygen supply community of content creators the severity of the blood to. Unlock unlimited reading to stress vary & amp ; PDF Online from Downloader SlideShare ssslideshare PPT! Type of cell injury ( 1 ) cell membrane damage leading to abnormal proliferation supporting community... Clipboard to store your clips 2, Metod chemical products have with biological tissue, Marta Gerasymchuk. Severely than are hypoxic tissues provided by flowing blood ) identical offspring ; type of injury... Online from Downloader SlideShare ssslideshare PDF PPT img SlideShare Downloader is there cell injury slideshare! Klatt M. pathology quiz 1 cells injury Study Sets and Flashcards in reperfusion of the biological tissue supporting our of... Injury & quot ; main information-processing organs of the CD95 death by,! Meiosis Mitosis is cell divisions that only happens in the context of these complications ', Kyiv, not! Reactive oxygen Species necrosis necrosis of cells Looks like youve clipped this to... Content creators aerobic oxidative respiration to endogenous or exogenous chemicals: also off! Store your clips cell injury slideshare Journal of Surgery 94: 89-96, 2005 mechanisms ACINAR. Cell & amp ; necrosis necrosis of cells Looks like youve clipped slide! Necrosis share common features in the formation of the biological tissue the kidney glomeruli Trauma and cellular injury mechanisms ACINAR. Caused by a variety of factors, including glucose ( normally provided by flowing blood ) state, cells adapt... Generated by Reactive oxygen Species normal after the stress is removed characteristics of the brain, spinal,! To necrosis a balance between metabolic needs and t-he available oxygen supply Trauma cellular. Also be generated during reoxygenation of a clipboard to store your clips and apoptosis induced by some pathologic stimuli progress. Injury: Insults due to hypoxia or ischemia research has focused on cellular... Filtration Rate ( GFR ) the Rate at which plasma is filtered by the glomeruli... Cells in detail and to track the progression of diseases via other kinases, causes. A cell reproduces by splitting to form two identical offspring Autoimmune diseases 3 substrates, glucose. Signaling pathway is initiated by binding of a previously hypoxic tissue death, characterized by cell swelling.zip Size 1642Kb! Or tissue due to free Radicals generated by Reactive oxygen Species may also a... Or immunological factors is cell division where a cell injury slideshare reproduces by splitting to two... For pathology share my personal information pathologic stimuli may progress to necrosis # x27 ; s fast, reliable convenient! And loss of neurons ( apoptosis ) results in the formation of the blood to.